Abstract |
Methyl beta-carboline-3-carboxylate ( beta-CCM) is a ligand for the benzodiazepine (BZD) binding site of the GABA-A receptors with convulsive properties. We provided evidence for the involvement of a fragment of mouse chromosomes 4 and 13 in beta-CCM-induced seizures in a previous paper. Here, we analyzed, through [3H]- flumazenil binding, whether central BZD binding sites could be involved in the physiological processes underlying these differences of genetic sensitivities. In the JE/Le strain, where the effects of the chromosome 4 fragment can be analyzed, we found associations between [3H]- flumazenil binding and the convulsive action of beta-CCM. On the contrary, this no longer holds true in C3XtEso strain, where the effects of the chromosome 13 fragment were observed.
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Authors | Y Clément, B Martin, D Bondoux, P Venault, J M Launay, G Chapouthier |
Journal | Neuroreport
(Neuroreport)
Vol. 11
Issue 10
Pg. 2157-61
(Jul 14 2000)
ISSN: 0959-4965 [Print] England |
PMID | 10923662
(Publication Type: Journal Article)
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Chemical References |
- Carbolines
- Convulsants
- Receptors, GABA-A
- Tritium
- Flumazenil
- beta-carboline-3-carboxylic acid methyl ester
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Topics |
- Animals
- Brain
(drug effects, metabolism)
- Carbolines
(pharmacology)
- Chromosome Mapping
- Convulsants
(pharmacology)
- Flumazenil
(pharmacokinetics)
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Radioligand Assay
- Receptors, GABA-A
(drug effects, physiology)
- Seizures
(chemically induced, genetics, physiopathology)
- Species Specificity
- Tritium
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