Abstract |
The chromosome 15q24 region, containing the CHRNA3/A5/B4 gene cluster, coding for the alpha3, alpha5 and beta4 subunits of neuronal nicotinic acetylcholine receptors, has been reported to be linked to autosomal dominant nocturnal frontal lobe epilepsy ( ADNFLE) in one family. However, nor the gene nor the mutation involved have been identified. We report the refined mapping of CHRNA3/A5/B4 cluster. Segregation analyses of CHRNA3/A5/B4 polymorphisms in families showing recombinations for 15q24 G¿en¿ethon STR markers allowed to position the cluster in a 0.6 cM interval, between STRs D15S1027 and D15S1005. This location is external to the 15q24-ADNFLE-linked region, therefore excluding the involvement of this cluster in the pathogenesis of ADNFLE in the 15q24-linked family. Moreover, these data provide more precise information for further linkage studies.
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Authors | M T Bonati, R Asselta, S Duga, L Ferini-Strambi, A Oldani, M Zucconi, M Malcovati, L Dalprà, M L Tenchini |
Journal | Neuroreport
(Neuroreport)
Vol. 11
Issue 10
Pg. 2097-101
(Jul 14 2000)
ISSN: 0959-4965 [Print] England |
PMID | 10923651
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Genetic Markers
- Protein Subunits
- Receptors, Nicotinic
- nicotinic receptor subunit alpha3
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Topics |
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Circadian Rhythm
- Consanguinity
- Epilepsy, Frontal Lobe
(genetics, physiopathology)
- Female
- Genetic Markers
- Humans
- Male
- Microsatellite Repeats
- Multigene Family
- Pedigree
- Polymorphism, Genetic
- Protein Subunits
- Receptors, Nicotinic
(genetics)
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