[Cellular biological mechanism of leukocytosis produced by all-trans retinoic acid: a preliminary study].

Abstract

OBJECTIVE:

To investigate the cellular biological mechanism of leukocytosis produced by all-trans retinoic acid (ATRA).

METHODS:

BALB/C mice were fed by ATRA. The effects of ATRA on BALB/C mice hematopoiesis was studied by 3H-TdR, semi-solid progenitor culture, and CFU-S number.

RESULTS:

ATRA increased the peripheral blood cells count in vivo. The effect on WBC count was obvious. The peak of the elevation (183% of the control) occurred at the 16th day. Correspondingly, 3H-TdR was increased and CFU-S was enhanced in BM, and the peak of the elevation (190% and 200% of the control, respectively) occurred at the 8th day. The progenitor cell CFU-GM was proliferated and the maximum elevation (215% of control) was observed at the 12th day.

CONCLUSION:

ATRA could produce leukocytosis in normal BALB/C mice. The effect was possibly related to the proliferation of CFU-GM and CFU-S and to ATRA-induced CSA such as G-CSF in vivo.

• Authors: H Chen, G Sun, J Li
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 78 Issue 4 Pg. 284-6 (Apr 1998) ISSN: 0376-2491 [Print] China
• PMID: 10923486 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tretinoin

Topics

• Animals
• Cell Division (drug effects)
• Hematopoietic Stem Cells (cytology)
• Leukocytosis (chemically induced)
• Male
• Mice
• Mice, Inbred BALB C
• Random Allocation
• Tretinoin (adverse effects)