Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSION: We conclude that morphine stimulates the generation of TNF-infinity by LPS-activated mesangial cells. This effect of morphine seems to be opiate receptor mediated and has a downstream effect in the form of mesangial cell nitrite generation. The present in vitro study provides the basis for a hypothesis that morphine may be playing a role in the development of heroin and HIV-associated nephropathies.
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Authors | A A Kapasi, N Gibbons, J Mattana, P C Singhal |
Journal | Inflammation
(Inflammation)
Vol. 24
Issue 5
Pg. 463-76
(Oct 2000)
ISSN: 0360-3997 [Print] United States |
PMID | 10921509
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Monoclonal
- Enzyme Inhibitors
- HIV Envelope Protein gp120
- Lipopolysaccharides
- Narcotic Antagonists
- Nitrites
- Tumor Necrosis Factor-alpha
- Naloxone
- Naltrexone
- Morphine
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Antibodies, Monoclonal
(pharmacology)
- Cell Line, Transformed
(drug effects, metabolism)
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Inhibitors
(pharmacology)
- Gene Expression Regulation
(drug effects)
- Glomerular Mesangium
(cytology, drug effects, metabolism)
- Glomerulosclerosis, Focal Segmental
(chemically induced)
- HIV Envelope Protein gp120
(physiology)
- HIV Infections
(complications)
- Heroin Dependence
(complications)
- Lipopolysaccharides
(pharmacology)
- Macrophages
(drug effects, metabolism)
- Mice
- Morphine
(antagonists & inhibitors, pharmacology)
- Muscle, Smooth, Vascular
(drug effects, metabolism)
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Naloxone
(pharmacology)
- Naltrexone
(pharmacology)
- Narcotic Antagonists
(pharmacology)
- Nitrites
(metabolism)
- Tumor Necrosis Factor-alpha
(biosynthesis, genetics)
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