Abstract | OBJECTIVE: DESIGN: Randomized, controlled trial. PARTICIPANTS: One hundred seventeen patients with a clinical diagnosis of viral conjunctivitis were randomized to the treatment group or control group. METHODS: Physicians and patients were masked to treatment. Patients in the treatment group received topical ketorolac 0.5% four times daily. Patients in the control group received artificial tears four times daily. Symptom and sign scores were recorded on the day of recruitment and at the time of a follow-up examination 3 to 4 days later. MAIN OUTCOME MEASURES: Change in six symptoms of conjunctivitis (overall discomfort, itching, foreign body sensation, tearing, redness, and lid swelling) and four signs of conjunctivitis (conjunctival injection, conjunctival chemosis, conjunctival mucus, and lid edema). Adverse effects were also studied. RESULTS: A total of 105 patients returned for their 3- to 4-day follow-up. Both the artificial tear and ketorolac groups showed improvement in all symptom scores at their 3- to 4-day follow-up visit. There was no statistically significant difference between the change in symptom scores between the treatment group and control group in any symptom category except redness. Patients in the control group were more likely to report improvement in redness than those in the treatment group, P = 0.012. There was no statistically significant difference between the change in sign scores between the treatment and control groups. Ketorolac 0.5% was more likely to produce stinging than artificial tears, 59.2% versus 18.8%, P < 0.001. CONCLUSIONS:
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Authors | Y Shiuey, B K Ambati, A P Adamis |
Journal | Ophthalmology
(Ophthalmology)
Vol. 107
Issue 8
Pg. 1512-7
(Aug 2000)
ISSN: 0161-6420 [Print] United States |
PMID | 10919900
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Ophthalmic Solutions
- Ketorolac
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Topics |
- Administration, Topical
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects, therapeutic use)
- Conjunctivitis, Viral
(drug therapy, physiopathology)
- Double-Blind Method
- Female
- Humans
- Ketorolac
(administration & dosage, adverse effects, therapeutic use)
- Male
- Ophthalmic Solutions
(administration & dosage, adverse effects, therapeutic use)
- Prospective Studies
- Surveys and Questionnaires
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