Abstract | OBJECTIVE: DESIGN: A multicenter, randomized, double-masked study. PARTICIPANTS: METHODS: MAIN OUTCOME MEASURES: Main outcome measures included the frequency, severity, and duration of ocular complications, patient reports of zoster-associated pain, and the outcome of skin lesions. Tolerance was also assessed on the incidence and types of adverse effects and changes in laboratory parameters. The analysis was mainly descriptive and performed on an intent-to-treat basis. RESULTS: Ocular complications of herpes zoster ophthalmicus were similar in the valaciclovir and acyclovir treatment groups. The main complications were conjunctivitis (54% and 52%, respectively), superficial keratitis (39% and 48%, respectively for punctate keratitis; 11% in each group for dendritic keratitis), stromal keratitis (13% in each group), and uveitis (13% and 17%, respectively). The long-term outcomes of these ocular complications were favorable and similar in both treatment groups. Pain duration and severity and outcome of skin lesions were similar between groups. Most patients reported prodromal pain. After 1 month, 25% of patients in the valaciclovir group and 31% in the acyclovir group still reported pain. The percentage of patients experiencing postherpetic neuralgia decreased during follow-up. The tolerance to acyclovir and valaciclovir was comparable and considered good. The most frequent adverse events were vomiting and edema of the eyelids or face (3%-5%). Three serious adverse events not linked to the study drugs occurred. CONCLUSIONS:
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Authors | J Colin, O Prisant, B Cochener, O Lescale, B Rolland, T Hoang-Xuan |
Journal | Ophthalmology
(Ophthalmology)
Vol. 107
Issue 8
Pg. 1507-11
(Aug 2000)
ISSN: 0161-6420 [Print] United States |
PMID | 10919899
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Tablets
- Valine
- Valacyclovir
- Acyclovir
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Topics |
- Acyclovir
(adverse effects, analogs & derivatives, therapeutic use)
- Administration, Oral
- Antiviral Agents
(adverse effects, therapeutic use)
- Conjunctivitis, Viral
(etiology, prevention & control)
- Double-Blind Method
- Female
- Herpes Zoster Ophthalmicus
(complications, drug therapy)
- Humans
- Immunocompetence
- Keratitis
(etiology, prevention & control)
- Male
- Middle Aged
- Pain
(etiology, prevention & control)
- Safety
- Tablets
- Uveitis
(etiology, prevention & control)
- Valacyclovir
- Valine
(adverse effects, analogs & derivatives, therapeutic use)
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