An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.

Abstract

Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.

• Authors: D K Kansal, A Chakrabarti
• Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol) Vol. 44 Issue 1 Pg. 57-63 (Jan 2000) ISSN: 0019-5499 [Print] India
• PMID: 10919096 (Publication Type: Journal Article)

Chemical References

• Convulsants
• Hypnotics and Sedatives
• Insecticides
• Organothiophosphorus Compounds
• Barbital
• methyl demeton
• Pentylenetetrazole

Topics

• Animals
• Barbital (pharmacology)
• Behavior, Animal (drug effects)
• Convulsants
• Electroshock
• Exploratory Behavior (drug effects)
• Female
• Hypnotics and Sedatives (pharmacology)
• Insecticides (toxicity)
• Male
• Neurotoxicity Syndromes (psychology)
• Organothiophosphorus Compounds (toxicity)
• Pentylenetetrazole
• Postural Balance (drug effects)
• Rats
• Rats, Sprague-Dawley
• Seizures (chemically induced, prevention & control)