Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: Cytotoxicity decreased as follows: BA > BMA > EA > MMA. Changes in phase transition properties (temperature Tm, enthalpy delta H and Height/Half-Height Width (H/HHW) of DSC peak were decreased as follows: BA > EA > MMA. BMA enhanced H/HHW and increased Tm slightly. NMR-shielding effect decreased as follows: BMA > MMA > BA, EA. CONCLUSION: BA and BMA exhibited large cytotoxicity and high DPPC-interaction due to their lipophilicity, compared to EA or MMA. MMA showed little cytotoxicity and small changes in DPPC liposomes, whereas BA showed large cytotoxicity and large changes in the liposomes characterized by the membrane disturbance. Haemolytic activity and cytotoxicity of acrylates were higher than those of methacrylates. The physico-chemical properties (Log P or Q sigma) of (meth) acrylates affect the lipid bilayer in biological membranes.
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Authors | S Fujisawa, T Atsumi, Y Kadoma |
Journal | Oral diseases
(Oral Dis)
Vol. 6
Issue 4
Pg. 215-21
(Jul 2000)
ISSN: 1354-523X [Print] Denmark |
PMID | 10918558
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acrylates
- Lipid Bilayers
- Liposomes
- Membranes, Artificial
- Methacrylates
- Mutagens
- Methylmethacrylate
- 1,2-Dipalmitoylphosphatidylcholine
- n-butyl acrylate
- ethyl acrylate
- butyl methacrylate
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Topics |
- 1,2-Dipalmitoylphosphatidylcholine
(chemistry)
- Acrylates
(chemistry, toxicity)
- Adenocarcinoma
(pathology)
- Calorimetry, Differential Scanning
- Chemical Phenomena
- Chemistry, Physical
- Erythrocytes
(cytology, drug effects)
- Fibroblasts
(cytology, drug effects)
- Gingiva
(cytology, drug effects)
- Hemolysis
- Humans
- Lipid Bilayers
(chemistry)
- Liposomes
- Magnetic Resonance Spectroscopy
- Membranes, Artificial
- Methacrylates
(chemistry, toxicity)
- Methylmethacrylate
(chemistry, toxicity)
- Mutagens
(chemistry, toxicity)
- Submandibular Gland Neoplasms
(pathology)
- Temperature
- Tumor Cells, Cultured
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