Alpha-L-fucosidase enzyme in the prediction of colorectal cancer patients at high risk of tumor recurrence.

Abstract

The aim of this study was to examine the prognostic value of the alpha-L-fucosidase enzyme to determine whether it can help in the early recognition of colorectal cancer cases at high risk of tumor recurrence. One hundred and twenty-three colorectal carcinoma patients treated by curative surgery were studied. The alpha-L-fucosidase activity was assayed in the tumor and in normal mucosa from each patient using a fluorometric method. Seven other clinical and pathologic features were also studied. To evaluate the impact of each variable over the disease-free interval, a postoperative 30-month follow-up of patients was performed, and a statistical survival analysis was carried out. The recurrence appearance was higher when the relative decrease of alpha-L-fucosidase activity was more than 52% (log-rank test, P = .0261). The results of this work indicate that alpha-L-fucosidase activity appears to be a good independent prognostic factor of tumoral recurrence in colorectal carcinoma.

• Authors: J Fernández-Rodríguez, D Ayude, M P de la Cadena, V S Martínez-Zorzano, A de Carlos, A Caride-Castro, G de Castro, F J Rodríguez-Berrocal
• Journal: Cancer detection and prevention (Cancer Detect Prev) Vol. 24 Issue 2 Pg. 143-9 ( 2000) ISSN: 0361-090X [Print] England
• PMID: 10917134 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• alpha-L-Fucosidase

Topics

• Adult
• Aged
• Aged, 80 and over
• Colorectal Neoplasms (enzymology, mortality, pathology)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (enzymology, mortality, pathology)
• Neoplasm Staging
• Prognosis
• Risk Factors
• Survival Analysis
• alpha-L-Fucosidase (metabolism)