The effect of SK-896 on post-operative ileus in dogs: gastrointestinal motility pattern and transit.

Abstract

The aim of this study was to investigate the effect of SK-896 (Phe-Val-Pro-Ile-Phe-Thr-Try-Gly-Glu-Leu-Gln-Arg-Leu-Gln-Glu-Lys-Glu- Arg-Asn-Lys-Gly-Gln-Hse), a new motilin analogue, on gastrointestinal motility and transit in dogs with post-operative ileus, and to compare the effects of this agent on these parameters with the effects of prostaglandin F(2alpha), a well-known gastroprokinetic agent. We used chronically implanted force transducers to measure motility and radiography of radio-opaque markers to measure transit. Infusion of SK-896 1 microgram/kg/h, for 20 min twice a day induced interdigestive migrating contractions-like motility. Infusion of prostaglandin F(2alpha), 20 microgram/kg/h, for 1 h twice a day induced continuous contractions in the distal part of the small intestine. The time of first appearance of interdigestive migrating contractions in the stomach (gastric-interdigestive migrating contractions) and the gastric emptying time of the solid marker with the administration of SK-896 were significantly less than those noted with the administration of prostaglandin F(2alpha). It appears that gastric-interdigestive migrating contractions play an important role in the transit of substances, especially solid substances, in the gastrointestinal tract. We conclude that SK-896, which induced gastric-interdigestive migrating contractions, is effective to induce early recovery from post-operative ileus.

• Authors: K Tsukamoto, M Mizutani, M Yamano, Y Tagi, M Takeda
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 401 Issue 1 Pg. 97-107 (Jul 28 2000) ISSN: 0014-2999 [Print] Netherlands
• PMID: 10915842 (Publication Type: Journal Article)

Chemical References

• SK896
• Motilin

Topics

• Amino Acid Sequence
• Animals
• Digestive System (drug effects, physiopathology)
• Digestive System Surgical Procedures
• Dogs
• Gastrointestinal Motility (drug effects)
• Gastrointestinal Transit (drug effects)
• Intestinal Obstruction (etiology, physiopathology, prevention & control)
• Male
• Molecular Sequence Data
• Motilin (analogs & derivatives, pharmacology)
• Myoelectric Complex, Migrating (drug effects)
• Postoperative Complications (etiology, physiopathology, prevention & control)
• Time Factors