Urinary steroid profile in adrenocortical tumors.

Abstract

Determination of the urinary steroid profile has been proposed as a sensitive tool for diagnosing adrenocortical tumors. The urinary steroid profiles were determined for patients with adrenocortical tumors. Urinary steroids were extracted, derivatized to form methyloxime-trimethylsilyl ether and analyzed by gas chromatography/mass spectrometry. Patients with adrenal adenomas from primary hyperaldosteronism had increased metabolites of 18-hydroxycorticosterone and aldosterone, and those with Cushing's syndrome had elevated excretion of 11 -deoxycortisol, cortisol, 18-hydroxycortisol, and cortisone metabolites. In patients with adrenocortical carcinomas, increased levels of metabolites of 11-deoxycortisol or 33-hydroxy-5-ene steroids were observed. The urinary steroid profiles of adrenal adenomas and adrenocortical carcinomas were quite different, suggesting the diagnostic validity for discriminating malignant from benign diseases.

• Authors: E Kikuchi, H Yanaihara, J Nakashima, K Homma, T Ohigashi, H Asakura, M Tachibana, H Shibata, T Saruta, M Murai
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 54 Suppl 1 Pg. 194s-197s (Jun 2000) ISSN: 0753-3322 [Print] France
• PMID: 10915023 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Steroids

Topics

• Adenoma (complications, urine)
• Adrenal Cortex Neoplasms (complications, urine)
• Carcinoma (complications, urine)
• Cushing Syndrome (urine)
• Diagnosis, Differential
• Humans
• Hyperaldosteronism (etiology, urine)
• Steroids (urine)