Congenital dyserythropoietic anemia type III associated with congenital atrioseptal defect has led to severe cardiac problems in a 32-year-old patient.

Abstract

We report the case of a 32-year-old woman who was admitted at hospital because of ortho-dyspnea, arrhythmia, and paleness. Clinical examination showed continuous arrhythmia, systolic heart murmur, enlargement of spleen and liver, and pathologic hematological parameters, thus indicating an intravasal hemolysis (elevated HBDH, bilirubin, and reticulocytes; reduced hemoglobin and haptoglobin levels), and bone-marrow-smears showed a typical cytomorphology of CDA III. The patient's diagnosis was heart failure caused by mitral valve insufficiency due to congenital atrioseptal defect associated with congenital dyserythropoietic anemia type III (CDA III).

• Authors: G Röhrig, H Kilter, D Beuckelmann, A Kröner, C Scheid, V Diehl, D Söhngen
• Journal: American journal of hematology (Am J Hematol) Vol. 64 Issue 4 Pg. 314-6 (Aug 2000) ISSN: 0361-8609 [Print] United States
• PMID: 10911387 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2000 Wiley-Liss, Inc.

Topics

• Adult
• Anemia, Dyserythropoietic, Congenital (complications, physiopathology)
• Female
• Heart Failure (etiology, physiopathology)
• Heart Septal Defects, Atrial (complications, physiopathology)
• Humans