To compare a novel
controlled-release formulation of
metoclopramide with placebo in patients with
cancer-associated
dyspepsia syndrome, 26 adult patients with a >/=1 month history of
cancer-associated
dyspepsia syndrome were randomized to receive either controlled-release
metoclopramide 40 mg every 12 hours or matching placebo for a period of 4 days. On day 5, patients crossed over to the alternate treatment for a further period of 4 days. Dose adjustments and rescue
antiemetics were permitted during both phases.
Nausea,
anorexia, bloating,
vomiting/retching, and drowsiness were assessed on a 100-mm VAS scale in a daily diary. On the last day of treatment of each phase,
nausea was significantly lower in the controlled-release
metoclopramide group compared to placebo (17 +/- 12 mm versus 12 +/- 10 mm).
Nausea scores tended to increase across days during the placebo phase and to decrease during the controlled-release
metoclopramide phase. There was a trend for improvement in the intensity of all symptoms on controlled-release
metoclopramide with the exception of appetite, but this trend only reached statistical significance for
nausea. The frequency and severity of elicited adverse events did not differ significantly between treatments, although drowsiness,
dizziness, and poor sleep were somewhat higher in the placebo group. In no case was it necessary to discontinue controlled-release
metoclopramide because of toxicity. These results indicate that controlled-release
metoclopramide reduces gastrointestinal symptoms in this population of advanced
cancer patients.