An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly.

Abstract

We describe a girl with DiGeorge anomaly and normal cytogenetic and molecular studies, whose clinical course was complicated by graft versus host disease caused by intrauterine materno-fetal transfusion, and several immunohematological alterations including a monoclonal gammapathy of undetermined significance (first IgG, which subsequently changed to IgM). The main clinical features and pathological findings are discussed.

• Authors: J G Ocejo-Vinyals, M J Lozano, P Sánchez-Velasco, J Escribano de Diego, J E Paz-Miguel, F Leyva-Cobián
• Journal: Archives of disease in childhood (Arch Dis Child) Vol. 83 Issue 2 Pg. 165-9 (Aug 2000) ISSN: 1468-2044 [Electronic] England
• PMID: 10906029 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin G
• Immunoglobulin M

Topics

• Child, Preschool
• Chimera
• Chromosomes, Human, Pair 22 (genetics)
• DiGeorge Syndrome (complications, genetics, immunology)
• Fatal Outcome
• Female
• Fetomaternal Transfusion (complications, genetics)
• Graft vs Host Disease (complications, immunology)
• Humans
• Immunoglobulin G (immunology)
• Immunoglobulin M (immunology)
• Pedigree
• Pregnancy
• T-Lymphocytes (immunology)