Abstract |
Major depression (MDD) following traumatic brain injury (TBI) is a common phenomenon. There are no adequate studies in the literature defining optimum treatments for this condition following TBI. The opportunity arose to analyse a group of patients who were included in a larger study of an antidepressant ( moclobemide). As the treatment, but not the delivery, was known, this has the status of an open study. Twenty-six patients with major depression of late onset (mean 4.67 years post-TBI) were identified (18 male, 8 female), with a mean age at injury 28.49 years. The group was moderately depressed with Hamilton Depression score (HAM-D) of 23.385 and moderately anxious with Hamilton Anxiety score (HAM-A) of 21.231. Mean HAM-D reduction was 81% and HAM-A reduction 81%. Of the 26 subjects 23 were defined as responders. Onset of action was rapid, with 17 responding by day 3. Irritability scores showed a mean reduction of 57% and pain scores a reduction of 39%. It is concluded that moclobemide may be an effective treatment for MDD following TBI, but properly controlled studies must be carried out to confirm this.
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Authors | G Newburn, R Edwards, H Thomas, J Collier, K Fox, C Collins |
Journal | Brain injury
(Brain Inj)
Vol. 13
Issue 8
Pg. 637-42
(Aug 1999)
ISSN: 0269-9052 [Print] England |
PMID | 10901691
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Brain Injuries
(complications, psychology)
- Child
- Depressive Disorder
(drug therapy, etiology)
- Female
- Humans
- Male
- Middle Aged
- Moclobemide
(therapeutic use)
- Psychiatric Status Rating Scales
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