Involvement of sigma 1 receptors in methamphetamine-induced behavioral sensitization in rats.

Abstract

MS-377 is a novel selective sigma(1) ligand, currently being developed for the treatment of schizophrenia. In the present study, we examined the effects of MS-377 on behavioral sensitization induced by subchronic treatment with methamphetamine. MS-377 was administered at doses of 1.875-15 mg/kg (p.o.), to rats, and methamphetamine was administered at doses of 2 mg/kg (i.p.), 60 min later once daily for 10 days. Repeated administration of methamphetamine caused enhanced stereotypy, and behavioral sensitization was developed. MS-377 did not affect the acute effects of methamphetamine. However, co-administration of MS-377 attenuated the development of methamphetamine-induced behavioral sensitization in a dose-dependent manner. These results suggested that sigma(1) receptors play an important role in the developmental period of behavioral sensitization induced by methamphetamine in rats.

• Authors: S Takahashi, T Miwa, K Horikomi
• Journal: Neuroscience letters (Neurosci Lett) Vol. 289 Issue 1 Pg. 21-4 (Jul 28 2000) ISSN: 0304-3940 [Print] Ireland
• PMID: 10899399 (Publication Type: Journal Article)

Chemical References

• 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl) piperazin-1-yl)methyl-2-pyrrolidinone tartrate
• Antipsychotic Agents
• Piperazines
• Pyrrolidines
• Receptors, sigma
• Tartrates
• sigma-1 receptor
• Methamphetamine
• Haloperidol

Topics

• Administration, Oral
• Animals
• Antipsychotic Agents (administration & dosage)
• Behavior, Animal (drug effects, physiology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Haloperidol (administration & dosage)
• Injections, Intraperitoneal
• Male
• Methamphetamine (administration & dosage)
• Piperazines (administration & dosage)
• Pyrrolidines (administration & dosage)
• Rats
• Rats, Wistar
• Receptors, sigma (physiology)
• Schizophrenia (drug therapy)
• Stereotyped Behavior (drug effects, physiology)
• Tartrates