Abstract |
Homozygous obese db/db (BKS-Lepr(db) and ob/ob (B6-Lep(ob)) mice were treated for 14 days with a continuous infusion of a fat emulsion (controls) or loaded with oleoyl-estrone at doses of 12.5 and 50 nmol/g x d using surgically inserted osmotic minipumps. Treatment with oleoyl-estrone resulted in a marked decrease in body weight in both strains, compared with the unchecked growth of controls. In db/db mice, plasma urea and insulin, as well as liver lipid decreased with treatment. In ob/ob mice, the effect on insulin was more marked, in parallel with higher plasma lipids pointing to increased fat mobilisation. The results suggest that oleoyl-estrone effects on body fat reserves and insulin resistance are not mediated by leptin, since ob/ob mice lack this hormone and in the db/db it is present but cannot induce effects because of defective leptin receptors; in both cases oleoyl-estrone treatment lowers body weight.
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Authors | M M Grasa, R Vilà, M Esteve, C Cabot, J A Fernandez-López, X Remesar, M Alemany |
Journal | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
(Horm Metab Res)
Vol. 32
Issue 6
Pg. 246-50
(Jun 2000)
ISSN: 0018-5043 [Print] Germany |
PMID | 10898555
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Obesity Agents
- Insulin
- Lipids
- Oleic Acids
- Estrone
- oleoyl-estrone
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Topics |
- Animals
- Anti-Obesity Agents
(pharmacology)
- Body Weight
(drug effects)
- Estrone
(analogs & derivatives, pharmacology)
- Female
- Insulin
(blood)
- Lipids
(blood)
- Mice
- Mice, Obese
- Oleic Acids
(pharmacology)
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