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Oleoyl-estrone lowers the body weight of both ob/ob and db/db mice.

Abstract
Homozygous obese db/db (BKS-Lepr(db) and ob/ob (B6-Lep(ob)) mice were treated for 14 days with a continuous infusion of a fat emulsion (controls) or loaded with oleoyl-estrone at doses of 12.5 and 50 nmol/g x d using surgically inserted osmotic minipumps. Treatment with oleoyl-estrone resulted in a marked decrease in body weight in both strains, compared with the unchecked growth of controls. In db/db mice, plasma urea and insulin, as well as liver lipid decreased with treatment. In ob/ob mice, the effect on insulin was more marked, in parallel with higher plasma lipids pointing to increased fat mobilisation. The results suggest that oleoyl-estrone effects on body fat reserves and insulin resistance are not mediated by leptin, since ob/ob mice lack this hormone and in the db/db it is present but cannot induce effects because of defective leptin receptors; in both cases oleoyl-estrone treatment lowers body weight.
AuthorsM M Grasa, R Vilà, M Esteve, C Cabot, J A Fernandez-López, X Remesar, M Alemany
JournalHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 32 Issue 6 Pg. 246-50 (Jun 2000) ISSN: 0018-5043 [Print] Germany
PMID10898555 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Obesity Agents
  • Insulin
  • Lipids
  • Oleic Acids
  • Estrone
  • oleoyl-estrone
Topics
  • Animals
  • Anti-Obesity Agents (pharmacology)
  • Body Weight (drug effects)
  • Estrone (analogs & derivatives, pharmacology)
  • Female
  • Insulin (blood)
  • Lipids (blood)
  • Mice
  • Mice, Obese
  • Oleic Acids (pharmacology)

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