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Amtolmetin guacyl versus piroxicam in patients with osteoarthritis.

Abstract
The efficacy and tolerability of amtolmetin guacyl (AMG), a new non-steroidal anti-inflammatory drug, were compared with piroxicam, in patients with osteoarthritis. In a randomized double-blind study patients with arthritis (n = 99) received either 600 mg AMG on an empty stomach or 20 mg of piroxicam on a full stomach, once daily for 30 days. All clinical parameters improved significantly with both drugs; there were no significant differences between the two treatments. Tolerability, assessed by the patients, was significantly better in the AMG group. In the piroxicam group nine of 50 patients withdrew because of side-effects (gastrointestinal) compared with two of 49 (nausea and headache) in the AMG group. There were three cases of perforation, ulcer and bleeding in the piroxicam group but no serious side-effects with AMG. Total numbers of side-effects were similar in the two groups, but epigastric and abdominal pain were more frequent and more intense with piroxicam. AMG was as effective as piroxicam in controlling the symptoms of osteoarthritis, but showed better gastrointestinal tolerability.
AuthorsF Montrone, S Santandrea, I Caruso, R Gerli, M E Cesarotti, P Frediani, R Bassani
JournalThe Journal of international medical research (J Int Med Res) 2000 Mar-Apr Vol. 28 Issue 2 Pg. 91-100 ISSN: 0300-0605 [Print] England
PMID10898121 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Pyrroles
  • ST 679
  • Piroxicam
  • Glycine
Topics
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, chemistry, therapeutic use)
  • Double-Blind Method
  • Drug Tolerance
  • Female
  • Glycine (administration & dosage, adverse effects, analogs & derivatives, chemistry, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis (drug therapy)
  • Piroxicam (administration & dosage, adverse effects, therapeutic use)
  • Pyrroles (administration & dosage, adverse effects, chemistry, therapeutic use)

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