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Treatment of murine cryptococcal meningitis with UR-9751 and UR-9746.

Abstract
In these studies, we compare the efficacy of two new azole antifungals with fluconazole in a murine model of cryptococcal meningitis. Mice were infected intracranially. Beginning one day later, groups of 7-10 mice were treated through to day 10 orally with UR-9751 or UR-9746 at 0.1, 0.25, 0.5, 1 or 10 mg kg(-1) day(-1) or fluconazole at 10 mg kg(-1) day(-1). At 10 mg kg(-1) day(-1), all three drugs prolonged survival over controls, but at 1 mg kg(-1) day(-1) only UR-9746 prolonged survival. Tissue counts were more varied on mice sacrificed 8 days after infection. In general, both UR drugs were equal or more potent than fluconazole, and UR-9751 was more effective than UR-9746.
AuthorsM I Restrepo, L K Najvar, F Barchiesi, M F Luther, J R Graybill
JournalMedical mycology (Med Mycol) Vol. 38 Issue 3 Pg. 221-4 (Jun 2000) ISSN: 1369-3786 [Print] England
PMID10892990 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antifungal Agents
  • Morpholines
  • Triazoles
  • UR 9746
  • UR 9751
  • Fluconazole
Topics
  • Animals
  • Antifungal Agents (pharmacology, therapeutic use)
  • Cryptococcus neoformans (drug effects)
  • Fluconazole (pharmacology, therapeutic use)
  • Meningitis, Cryptococcal (drug therapy)
  • Mice
  • Microbial Sensitivity Tests
  • Morpholines (pharmacology, therapeutic use)
  • Survival Rate
  • Triazoles (pharmacology, therapeutic use)

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