Abstract |
In these studies, we compare the efficacy of two new azole antifungals with fluconazole in a murine model of cryptococcal meningitis. Mice were infected intracranially. Beginning one day later, groups of 7-10 mice were treated through to day 10 orally with UR-9751 or UR-9746 at 0.1, 0.25, 0.5, 1 or 10 mg kg(-1) day(-1) or fluconazole at 10 mg kg(-1) day(-1). At 10 mg kg(-1) day(-1), all three drugs prolonged survival over controls, but at 1 mg kg(-1) day(-1) only UR-9746 prolonged survival. Tissue counts were more varied on mice sacrificed 8 days after infection. In general, both UR drugs were equal or more potent than fluconazole, and UR-9751 was more effective than UR-9746.
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Authors | M I Restrepo, L K Najvar, F Barchiesi, M F Luther, J R Graybill |
Journal | Medical mycology
(Med Mycol)
Vol. 38
Issue 3
Pg. 221-4
(Jun 2000)
ISSN: 1369-3786 [Print] England |
PMID | 10892990
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antifungal Agents
- Morpholines
- Triazoles
- UR 9746
- UR 9751
- Fluconazole
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Topics |
- Animals
- Antifungal Agents
(pharmacology, therapeutic use)
- Cryptococcus neoformans
(drug effects)
- Fluconazole
(pharmacology, therapeutic use)
- Meningitis, Cryptococcal
(drug therapy)
- Mice
- Microbial Sensitivity Tests
- Morpholines
(pharmacology, therapeutic use)
- Survival Rate
- Triazoles
(pharmacology, therapeutic use)
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