HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Spectrin changes occur in erythrocytes from patients with Fanconi's anemia and their parents.

Abstract
Fanconi's anemia (FA) is a clinically and genetically heterogeneous disease which has been hypothesized to be defective in the detoxification of reactive oxygen species. In this work we report the results obtained by morphometric analyses on the red blood cells (RBCs) from FA patients and their parents. We found that a high rate of erythrocytes from both homozygous and heterozygous subjects was significantly altered. RBCs underwent in fact cytoskeleton-dependent modifications, in particular of spectrin molecule, leading to cell shrinking and blebbing. We hypothesize that these changes may be the result of an oxidative imbalance that probably lead to alterations of RBC plasticity- and deformation-associated functions. Moreover, our results also suggest the possibility to identify FA carriers by the existence of RBC abnormalities.
AuthorsE Straface, R Masella, D Del Principe, C Franceschi, L G Korkina, A Zatterale, G Pagano, W Malorni
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 273 Issue 3 Pg. 899-901 (Jul 14 2000) ISSN: 0006-291X [Print] United States
PMID10891344 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2000 Academic Press.
Chemical References
  • Spectrin
Topics
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Erythrocytes (metabolism)
  • Fanconi Anemia (blood, genetics)
  • Heterozygote
  • Humans
  • Phenotype
  • Spectrin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: