Abstract | OBJECTIVE: DESIGN: Prospective double-blind randomized trial. SETTING:
Burn treatment center of an army hospital. PATIENTS: Forty-seven severe burn patients with total burned body surface areas of 25% to 95% and presence of full thickness burn who were prescribed early exclusive enteral nutrition. Either ornithine alpha-ketoglutarate or isonitrogenous control ( soy protein mixture, Protil-1) were administered twice a day as a bolus (2 x 10 g) at 9 am and 9 pm for 3 wks. The patients were evaluated for wound healing time (primary end point), antibiotic use, tolerance, duration of enteral nutrition, and nutritional status. INTERVENTIONS: Serial blood samples were collected in each patient for determination of serum transthyretin and plasma phenylalanine, and urine sampling was performed for determination of 3-methylhistidine excretion at day 4 and day 21 after burn injury. MEASUREMENTS AND MAIN RESULTS: Wound healing times in patients receiving ornithine alpha-ketoglutarate or Protil-1 were 60 +/- 7 and 90 +/- 12 days, respectively (p < .05) for similar grafted surfaces. Based on increased serum transthyretin concentrations, both groups showed an improvement of nutritional status at day 21 after burn. Taking a cut-off value of 110 unit burn standard for severity of injury, plasma phenylalanine concentrations, and urinary 3- methylhistidine/ creatinine ratio were significantly reduced (p < .05) in the less severe burn patients (<110 unit burn standard) supplemented with ornithine alpha-ketoglutarate. CONCLUSIONS:
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Authors | C Coudray-Lucas, H Le Bever, L Cynober, J P De Bandt, H Carsin |
Journal | Critical care medicine
(Crit Care Med)
Vol. 28
Issue 6
Pg. 1772-6
(Jun 2000)
ISSN: 0090-3493 [Print] United States |
PMID | 10890617
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Soybean Proteins
- ornithine alpha-ketoglutarate
- Ornithine
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Topics |
- Adult
- Burns
(drug therapy)
- Double-Blind Method
- Enteral Nutrition
- Female
- Humans
- Injury Severity Score
- Male
- Ornithine
(analogs & derivatives, therapeutic use)
- Prospective Studies
- Soybean Proteins
(therapeutic use)
- Wound Healing
(drug effects)
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