Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats.

Abstract

The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.

• Authors: I Oosuka, Y Tanaka, N Miura, K Yamanouchi
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 83 Issue 1 Pg. 82-5 (May 2000) ISSN: 0021-5198 [Print] Japan
• PMID: 10887944 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1-(3-(2-indanylacetyl)-L-thioprolyl)pyrrolidine
• Protease Inhibitors
• Pyrrolidines
• Vasopressins
• Cholecystokinin
• Serine Endopeptidases
• PREPL protein, human
• Prolyl Oligopeptidases

Topics

• Animals
• Cholecystokinin (physiology)
• Female
• Motor Activity (drug effects)
• Posture
• Prolyl Oligopeptidases
• Protease Inhibitors (pharmacology)
• Pyrrolidines (pharmacology)
• Rats
• Rats, Wistar
• Serine Endopeptidases (physiology)
• Sexual Behavior, Animal (drug effects)
• Vasopressins (physiology)