Paracoccidioidomycosis (South American blastomycosis) successfully treated with terbinafine: first case report.

Abstract

We describe a 63-year-old man who presented with painful malodorous lesions in the perianal, perineal and scrotal regions. Following definitive diagnosis of paracoccidioidomycosis, he was treated initially with trimethoprim/sulphamethoxazole, but there was no clinical improvement. He then received terbinafine (Lamisil) 250 mg twice daily for 6 months. There was rapid resolution of all lesions and complete relief of symptoms, without any associated side-effects. The patient remains clinically well and without any evidence of infection 2 years after discontinuation of terbinafine treatment.

• Authors: J M Ollague, A M de Zurita, G Calero
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 143 Issue 1 Pg. 188-91 (Jul 2000) ISSN: 0007-0963 [Print] England
• PMID: 10886159 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Naphthalenes
• Trimethoprim, Sulfamethoxazole Drug Combination
• Terbinafine

Topics

• Antifungal Agents (therapeutic use)
• Humans
• Male
• Middle Aged
• Naphthalenes (therapeutic use)
• Paracoccidioidomycosis (drug therapy)
• Perineum
• Scrotum
• Terbinafine
• Treatment Outcome
• Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)