Association analysis of the 5-HT5A gene in depression, psychosis and antipsychotic response.

Abstract

The serotonergic system is targeted by both antidepressants and atypical antipsychotic drugs such as clozapine. Genetic variation in the 5-HT5A gene might be involved in susceptibility to depression, the major psychoses or in influencing clinical response to treatment. To examine this hypothesis we genotyped two polymorphisms (-19G/C; 12A/T) in the human 5-HT5A receptor gene in a sample of 269 unrelated schizophrenic patients treated with clozapine, 112 bipolar patients, 75 unipolar patients and 187 controls. After five-fold correction for multiple testing, allelic association was found with the -19G/C polymorphism and bipolar affective disorder, (p = 0.025; OR 0.56), unipolar depression (p = 0.004; OR 0.52) and schizophrenia (p = 0.036; OR 0.67) indicating a potential protective effect of the G19 allele. For the 12A/T polymorphism allelic association was observed with unipolar depression only (p = 0.004). We conclude that allelic variation in the human 5-HT5A receptor gene may be involved in susceptibility to schizophrenia and affective disorders but not in determining response to clozapine.

• Authors: J T Birkett, M J Arranz, J Munro, S Osbourn, R W Kerwin, D A Collier
• Journal: Neuroreport (Neuroreport) Vol. 11 Issue 9 Pg. 2017-20 (Jun 26 2000) ISSN: 0959-4965 [Print] England
• PMID: 10884063 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Receptors, Serotonin
• serotonin 5 receptor
• Clozapine

Topics

• Alleles
• Antipsychotic Agents (therapeutic use)
• Bipolar Disorder (genetics)
• Clozapine (therapeutic use)
• Depression (genetics)
• Humans
• Polymorphism, Genetic
• Psychotic Disorders (drug therapy, genetics)
• Receptors, Serotonin (genetics)
• Reference Values
• Schizophrenia (drug therapy, genetics)