Abstract | BACKGROUND: Using the human fibroblast growth factor we could already demonstrate the induction of neoangiogenesis in the ischemic human myocardium. METHODS: Forty patients, who were undergoing elective coronary artery bypass grafting were randomly selected and allotted either to a treatment or a control group. In 20 patients (study group) fibroblast growth factor was injected directly into the myocardium, close to the left anterior descending coronary artery. The control group comprised 20 patients who had been injected with heat denatured fibroblast growth factor. The 3-year follow-up consisted of a clinical examination, echocardiography, and selective imaging of the internal mammary artery bypass using angiography. RESULTS: As with the early results, a dense new capillary network could be demonstrated angiographically in the region where the factor had been injected. Echocardiography showed an increase in the left ventricular ejection fraction in the study group. We also found a more pronounced improvement in the clinical appearance of the patients with fibroblast growth factor. CONCLUSIONS:
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Authors | P Pecher, B A Schumacher |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 69
Issue 5
Pg. 1414-9
(May 2000)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 10881815
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Fibroblast Growth Factors
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Topics |
- Coronary Angiography
- Coronary Disease
(pathology)
- Echocardiography
- Female
- Fibroblast Growth Factors
(pharmacology)
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Myocardium
(pathology)
- Neovascularization, Physiologic
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