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Biodegradable scleral implant for controlled intraocular delivery of betamethasone phosphate.

Abstract
We evaluated nail-like, biodegradable scleral implants as a controlled intraocular delivery system of betamethasone phosphate (BP) for the treatment of chronic uveitis using pigmented rabbits. The scleral implants, which contained 10% and 25% of BP (weight 8.5 mg; length 5 mm), were made of poly (D,L-lactide-co-glycolide) (PLGA). In vivo release and retinal toxicity after implantation were also studied in pigmented rabbits. The in vitro release studies demonstrated the 10% and 25% BP-loaded scleral implants released BP in a biphasic release pattern for at least 1 month. The BP concentrations in the vitreous and the retina/choroid after application of scleral implants in pigmented rabbit eyes stayed within the concentration range capable of suppressing inflammatory responses for over 1 month. The BP concentration was greater in the retina/choroid than in the vitreous throughout the study. No substantial toxic reactions in the retina were observed by electroretinography. Our findings suggest that the BP-loaded scleral implant may be a promising device for treatment of chronic uveitis.
AuthorsN Kunou, Y Ogura, Y Honda, S H Hyon, Y Ikada
JournalJournal of biomedical materials research (J Biomed Mater Res) Vol. 51 Issue 4 Pg. 635-41 (Sep 15 2000) ISSN: 0021-9304 [Print] United States
PMID10880111 (Publication Type: Journal Article)
Chemical References
  • Biocompatible Materials
  • Drug Implants
  • Glucocorticoids
  • betamethasone sodium phosphate
  • Betamethasone
Topics
  • Animals
  • Betamethasone (administration & dosage, analogs & derivatives, pharmacokinetics, toxicity)
  • Biocompatible Materials
  • Biodegradation, Environmental
  • Chronic Disease
  • Drug Delivery Systems
  • Drug Implants
  • Electroretinography
  • Eye (drug effects, metabolism)
  • Glucocorticoids (administration & dosage, pharmacokinetics, toxicity)
  • In Vitro Techniques
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Rabbits
  • Sclera
  • Uveitis (drug therapy)

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