Abstract | BACKGROUND: OBJECTIVES: This study was designed to assess the long-term effects of lisinopril on mortality, cardiac function, and ventricular fibrosis after MI, in rats. METHODS: RESULTS: The mortality rate was reduced by 39 % in early treatment and 30 % in delayed treatment in comparison to the untreated rats. Early treatment reduced cardiac dysfunction in small MIs; however, delayed treatment did not. No statistical difference was observed among the groups for large MIs. No statistical difference was observed among the groups with large or small MIs on myocardial hydroxyproline concentration. CONCLUSIONS: Both early and delayed treatments with lisinopril increased survival. Treatment exerts no marked effects on fibrosis; early treatment has exerted beneficial influences on cardiac function whereas delayed treatment had no consistent effects. The protective effect of lisinopril is detectable only in small (< 40 % of LV) MIs.
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Authors | L A Zornoff, B B Matsubara, L S Matsubara, S A Paiva, J Spadaro |
Journal | Basic research in cardiology
(Basic Res Cardiol)
Vol. 95
Issue 3
Pg. 208-14
(Jun 2000)
ISSN: 0300-8428 [Print] Germany |
PMID | 10879622
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Lisinopril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Animals
- Diastole
- Fibrosis
- Heart
(drug effects)
- Lisinopril
(administration & dosage, therapeutic use)
- Male
- Myocardial Infarction
(drug therapy, mortality, pathology, physiopathology)
- Myocardium
(pathology)
- Pressure
- Rats
- Rats, Wistar
- Survival Analysis
- Systole
- Time Factors
- Ventricular Function, Left
(drug effects)
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