Involvement of nitric oxide from nerves on diarrhea induced by castor oil in rats.

Abstract

Nitric oxide (NO) is involved in the mechanism of castor oil-induced diarrhea. This study was performed to elucidate the source of NO. Diarrhea was induced by oral administration of castor oil in rats. Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole. This effect was attenuated by the treatment with L-arginine. Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea. N(G)-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats. These data suggest, at least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.

• Authors: M Uchida, Y Kato, K Matsueda, R Shoda, A Muraoka, S Yamato
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 82 Issue 2 Pg. 168-70 (Feb 2000) ISSN: 0021-5198 [Print] Japan
• PMID: 10877537 (Publication Type: Journal Article)

Chemical References

• Nitric Oxide
• Castor Oil
• NG-Nitroarginine Methyl Ester

Topics

• Animals
• Castor Oil (toxicity)
• Diarrhea (chemically induced)
• Dose-Response Relationship, Drug
• Male
• NG-Nitroarginine Methyl Ester (pharmacology)
• Nitric Oxide (physiology)
• Rats
• Rats, Sprague-Dawley