Abstract | BACKGROUND: The aim of this study was to assess the value of technetium 99m-MIBI scintigraphy using the single photon emission computed tomography (SPECT) technique for preoperative localization of smaller (</= 1 g) parathyroid adenomas. METHODS: RESULTS: All patients had parathyroid adenomas </= 1 g (53 patients, 0.5 -1.0 g; 39 patients, < 0.5 g). Correct localization of parathyroid adenomas to one side or the other was achieved in 87% of the patients using planar technetium 99m- pertechnetate/technetium 99m-MIBI subtraction scintigraphy. Sensitivity was increased to 95% by supplementary use of the SPECT technique and a 3-D display (volume-rendered reprojection for visualization). There was technetium 99m-MIBI accumulation in 11 benign thyroid nodes, but none of the healthy parathyroid glands were shown on the scan. CONCLUSIONS: This study indicates that technetium 99m-MIBI parathyroid scintigraphy is a sensitive and specific tool for topographic localization even of small parathyroid adenomas, especially with the use of SPECT. This method could help to improve the efficiency of parathyroidectomy (eg, by making unilateral exploration sufficient).
|
Authors | D Moka, E Voth, M Dietlein, A Larena-Avellaneda, H Schicha |
Journal | Surgery
(Surgery)
Vol. 128
Issue 1
Pg. 29-35
(Jul 2000)
ISSN: 0039-6060 [Print] United States |
PMID | 10876182
(Publication Type: Journal Article)
|
Chemical References |
- Radiopharmaceuticals
- Technetium Tc 99m Sestamibi
|
Topics |
- Adenoma
(diagnostic imaging, surgery)
- Aged
- Female
- Humans
- Male
- Middle Aged
- Parathyroid Neoplasms
(diagnostic imaging, surgery)
- Radiopharmaceuticals
- Sensitivity and Specificity
- Technetium Tc 99m Sestamibi
- Tomography, Emission-Computed, Single-Photon
|