The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose.

Abstract

We screened the peroxisome proliferator activated receptor gamma 2 (PPAR gamma 2) for sequence variants in 165 unrelated obese (BMI >/= 30 kg/m(2)) Caucasian women, and 49 normal weight Caucasian female controls (BMI < 27 kg/m(2)). The allele frequency of the Pro12Ala mutation was higher in obese(18.18%) than in normal weight women (8. 16%) (chi(2)((1)) = 5.68, P = 0.017). Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9. 4 years; Pro/Ala+Ala/Ala 8.6 +/- 7.1 years, P = 0.005), was associated with lower fasting glucose and was protective against type II diabetes.

• Authors: W D Li, J H Lee, R A Price
• Journal: Molecular genetics and metabolism (Mol Genet Metab) Vol. 70 Issue 2 Pg. 159-61 (Jun 2000) ISSN: 1096-7192 [Print] United States
• PMID: 10873398 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright 2000 Academic Press.

Chemical References

• Blood Glucose
• Nuclear Proteins
• Receptors, Cytoplasmic and Nuclear
• Transcription Factors
• DNA

Topics

• Adult
• Age of Onset
• Alleles
• Blood Glucose (metabolism)
• DNA (analysis)
• Diabetes Mellitus, Type 2 (prevention & control)
• Female
• Gene Frequency
• Humans
• Mutation
• Nuclear Proteins (genetics)
• Obesity, Morbid (blood, ethnology, genetics)
• Phenotype
• Receptors, Cytoplasmic and Nuclear (genetics)
• Transcription Factors (genetics)
• White People