Intrauterine infection, magnesium sulfate exposure and cerebral palsy in infants born between 26 and 30 weeks of gestation.

Abstract

OBJECTIVE:

To identify prenatal events associated with cerebral palsy (CP) in infants born between 26 and 30 weeks of gestation.

STUDY DESIGN:

Case (n=22)-control (n=170) study was performed using a logistic regression model.

RESULTS:

Significant association of intrauterine infection with increased risk of CP was found in a logistic regression model that controlled for abnormal FHR patterns, placental infection, fetal acidosis at birth (umbilical artery pH<7. 1), and low Apgar score (<7) (odds ratio (OR) 5.47, 95% confidence interval (CI) 1.46-20.4). Magnesium sulfate exposure was associated with decreased risk (OR 0.13, CI 0.03-0.66) after exclusion of premature rupture of the membranes and abruptio placentae. In the magnesium exposure group, cases were infants born less than 28 weeks of gestation (3/21 vs. 0/61, P=0.015).

CONCLUSION:

In this case-control study, both intrauterine infection and magnesium sulfate exposure were significant factors related to the occurrence of cerebral palsy.

• Authors: Y Matsuda, S Kouno, Y Hiroyama, K Kuraya, M Kamitomo, S Ibara, M Hatae
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 91 Issue 2 Pg. 159-64 (Aug 2000) ISSN: 0301-2115 [Print] Ireland
• PMID: 10869789 (Publication Type: Journal Article)

Chemical References

• Magnesium Sulfate

Topics

• Abruptio Placentae (complications)
• Adolescent
• Adult
• Birth Weight
• Case-Control Studies
• Cerebral Palsy (etiology)
• Female
• Fetal Membranes, Premature Rupture (complications)
• Gestational Age
• Heart Rate, Fetal
• Humans
• Logistic Models
• Magnesium Sulfate (administration & dosage)
• Maternal Age
• Pregnancy
• Pregnancy Complications, Infectious
• Pregnancy, High-Risk
• Risk Factors
• Uterine Diseases (complications)