HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Cyclosporine A-associated fatal central nervous system angiopathy in a bone marrow transplant recipient: an autopsy case.

Abstract
We report here the case of a 32-year-old woman who suffered from a unique angiopathy in the central nervous system (CNS). She died of multiple infarcts in the brain stem and cerebellum during treatment with cyclosporine A after bone marrow transplantation for refractory anemia with excess of blasts. The autopsy findings showed segmental narrowing of the basilar artery, in which circumferential dissection of the internal elastic lamina had occurred. The distal portion of the basilar artery was obstructed by upward dislocation of the dissected intima. Similar angiopathy was also observed at multiple sites along the basilar artery branches. These findings suggest endothelial damage, including vasoconstriction and dissection of the CNS arteries.
AuthorsT Koide, M Yamada, T Takahashi, S Igarashi, M Masuko, T Furukawa, T Kuroha, T Koike, M Sato, R Tanaka, S Tsuji, H Takahashi
JournalActa neuropathologica (Acta Neuropathol) Vol. 99 Issue 6 Pg. 680-4 (Jun 2000) ISSN: 0001-6322 [Print] GERMANY
PMID10867802 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cyclosporine
Topics
  • Adult
  • Bone Marrow Transplantation (adverse effects)
  • Brain (drug effects, pathology)
  • Central Nervous System Diseases (chemically induced, pathology, physiopathology)
  • Cerebral Arteries (drug effects, pathology, physiopathology)
  • Cerebrovascular Circulation
  • Cyclosporine (adverse effects)
  • Fatal Outcome
  • Female
  • Humans
  • Peripheral Vascular Diseases (chemically induced, pathology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: