The inhibitory effect of the imidazoquinolinamine S-28828 on the pathogenesis of a type II adenovirus in turkeys.

Abstract

In this study we show that a type I-IFN inducing compound, S-28828, modulated the pathogenesis of an avian type II adenovirus in turkeys. By itself, S-28828 induced a strong reaction in the spleen characterized by hyperplasia of the red and white pulps as well as an increase in lymphoid cell aggregations. Oral administration of S-28828 before the time of virus inoculation suppressed significantly (P<0.05) the replication of hemorrhagic enteritis virus (HEV) in turkeys. Two doses of 5 or 50 mg of S-28828 administered at 2 days before and at the day of virus inoculation inhibited HEV-induced pathological and histopathological lesions. Virus-induced apoptosis and reduced IgM-surface expression of B cells were suppressed by low dose S-28828 treatment. These results are of interest because mammalian adenoviruses were shown to be resistant to antiviral effects of type I IFN, the major effector cytokine induced by S-28828.

• Authors: S Rautenschlein, R L Miller, J M Sharma
• Journal: Antiviral research (Antiviral Res) Vol. 46 Issue 3 Pg. 195-205 (Jun 2000) ISSN: 0166-3542 [Print] Netherlands
• PMID: 10867157 (Publication Type: Journal Article)

Chemical References

• Aminoquinolines
• Interferon Inducers
• S 28828

Topics

• Adenoviridae Infections (drug therapy, veterinary, virology)
• Aminoquinolines (therapeutic use)
• Animals
• Aviadenovirus (drug effects, pathogenicity, physiology)
• Enteritis (drug therapy, veterinary, virology)
• Gastrointestinal Hemorrhage (drug therapy, veterinary, virology)
• Interferon Inducers (therapeutic use)
• Poultry Diseases (drug therapy, virology)
• Turkeys
• Virulence
• Virus Replication (drug effects)