HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Regional haemodynamic effects of recombinant murine or human leptin in conscious rats.

Abstract
Regional haemodynamic responses to recombinant murine or human leptin were assessed in conscious, chronically-instrumented, male, Long-Evans rats (350 - 450 g). Human, but not murine, leptin caused a slight hindquarters vasoconstriction, but neither peptide had any effect on mean arterial blood pressure or heart rate. In the presence of the beta(2)-adrenoceptor antagonist, ICI 118551, a hindquarters vasoconstrictor response to human leptin was not seen, and there was a tachycardia, as there was to murine leptin. The nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, (L-NAME), did not influence the cardiovascular effects of murine or human leptin. The results indicate that the previously reported sympathoexcitatory effects of murine leptin in anaesthetized rats are not manifest as regional haemodynamic changes in conscious rats, and this is not due to beta(2)-adrenoceptor-mediated vasodilator mechanisms opposing any vasoconstrictor responses. Moreover, the ability of L-NAME to unmask a pressor effect of murine leptin in anaesthetized rats may not be apparent in the conscious state.
AuthorsS M Gardiner, P A Kemp, J E March, T Bennett
JournalBritish journal of pharmacology (Br J Pharmacol) Vol. 130 Issue 4 Pg. 805-10 (Jun 2000) ISSN: 0007-1188 [Print] England
PMID10864886 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Enzyme Inhibitors
  • Leptin
  • Propanolamines
  • Recombinant Proteins
  • ICI 118551
  • Nitric Oxide Synthase
  • NG-Nitroarginine Methyl Ester
Topics
  • Adrenergic beta-Antagonists (pharmacology)
  • Animals
  • Blood Circulation (drug effects)
  • Blood Pressure (drug effects)
  • Consciousness
  • Enzyme Inhibitors (pharmacology)
  • Heart Rate (drug effects)
  • Hemodynamics (drug effects)
  • Hindlimb (blood supply)
  • Humans
  • Kidney (blood supply)
  • Leptin (pharmacology)
  • Male
  • Mesentery (blood supply)
  • Mice
  • NG-Nitroarginine Methyl Ester (pharmacology)
  • Nitric Oxide Synthase (antagonists & inhibitors)
  • Propanolamines (pharmacology)
  • Rats
  • Rats, Long-Evans
  • Recombinant Proteins (pharmacology)
  • Regional Blood Flow (drug effects)
  • Vascular Resistance (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: