HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A Kampo medicine "Juzen-taiho-to"--prevention of malignant progression and metastasis of tumor cells and the mechanism of action.

Abstract
Juzen-taiho-to is a Kampo (Japanese and Chinese traditional) medicine, and is a nourishing agent, a so-called "Hozai" (in Japanese), that is used for improving disturbances and imbalances in the homeostatic condition of the body. This drug is administered to patients in various weakened conditions, including post-surgery patients and patients with chronic illnesses, where it can alleviate general symptoms such as extreme fatigue, pale complexion, loss of appetite, dry or scaly skin, night sweating, and dryness of the mouth. Currently, Juzen-taiho-to is often administered to cancer patients, and has been shown to possess various biological activities, such as enhancement of phagocytosis, cytokine induction, antibody production, induction of the mitogenic activity of spleen cells, anti-tumor effects when combined with surgical excision, anti-tumor effects with or without other drugs, and protection against the deleterious effects of anti-cancer drugs as well as radiation-induced immunosuppression and bone marrow toxicity. This article focuses on the antitumor and antimetastatic properties of Kampo formulations and describes the effect of Juzen-taiho-to and related formulations on tumor development, progression and metastasis in vivo. We also discuss the mechanism of the inhibitory action and the importance of the formulation and the constituent drugs in determining the efficacy.
AuthorsI Saiki
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 23 Issue 6 Pg. 677-88 (Jun 2000) ISSN: 0918-6158 [Print] Japan
PMID10864015 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Drugs, Chinese Herbal
  • Immunologic Factors
  • juzentaihoto
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Disease Progression
  • Drugs, Chinese Herbal (chemistry, pharmacology)
  • Humans
  • Immunologic Factors (chemistry, pharmacology)
  • Medicine, Kampo
  • Neoplasm Metastasis (prevention & control)
  • Neoplasms (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: