HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Riboflavin deficiency and preeclampsia.

AbstractOBJECTIVE:
To examine in a prospective study riboflavin deficiency as a predisposing factor for preeclampsia in a high-risk collective of pregnant women in Zimbabwe.
METHODS:
At an antenatal clinic in Bulawayo, Zimbabwe, 154 women at increased risk for preeclampsia were observed prospectively until delivery. Riboflavin status was determined using the erythrocyte glutathione reductase activation coefficient test on the day of antenatal booking. Riboflavin deficiency was expressed by erythrocyte glutathione reductase activation coefficient of 1.4 or greater.
RESULTS:
Riboflavin deficiency was frequently found among the study population (33.8%). Incidence rose toward the end of pregnancy (27.3% at 29-36 weeks' gestation compared with 53.3% at over 36 weeks). In the riboflavin-deficient group, mothers were more likely to develop preeclampsia (28.8%) than in the riboflavin-adequate group (7.8%; P <.001, odds ratio [OR] 4.7, 95% confidence interval [CI] 1.8-12.2). The calculated concentrations of intracellular free flavin adenine dinucleotide were significantly lower in patients who developed preeclampsia than in normal pregnancies (P <.05).
CONCLUSION:
Riboflavin deficiency should be considered a possible risk factor for preeclampsia. Insufficient concentrations of the riboflavin-derived cofactors flavin adenine dinucleotide and flavin adenine mononucleotide could contribute to the established pathophysiologic changes including mitochondrial dysfunction, enhanced oxidative stress, and disturbances in nitric oxide release.
AuthorsJ Wacker, J Frühauf, M Schulz, F M Chiwora, J Volz, K Becker
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 96 Issue 1 Pg. 38-44 (Jul 2000) ISSN: 0029-7844 [Print] United States
PMID10862839 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glutathione Reductase
Topics
  • Adult
  • Female
  • Glutathione Reductase (blood)
  • Humans
  • Pre-Eclampsia (epidemiology)
  • Pregnancy
  • Pregnancy, High-Risk
  • Prospective Studies
  • Riboflavin Deficiency (epidemiology)
  • Risk Factors
  • Zimbabwe (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: