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Role of progestins in the premenopausal climacteric.

AbstractBoth the prevention of diseases and therapy of symptoms in premenopausal women is a demanding task for the gynecologist. Present day knowledge allows a differentiated approach for the use of the various progestins in the premenopausal period. A women-specific medicine needs individual selection of the progestins, both for substitution and treatment. The various partial effects of the progestins, such as androgenic, antiandrogenic, estrogenic, antiestrogenic, glucocorticoid etc., have to be taken into account and should be applied according to the individuals' needs. The benefits of progestins can be obtained in various clinical conditions, including bleeding disorders; benign proliferative diseases (such as benign breast disease, endometrial hyperplasia and endometriosis); contraception; androgenization; and gynecological oncology.
AuthorsA E Schindler (Affiliation: Department of Obstetrics and Gynecology, University of Essen, Germany.)
JournalGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 13 Suppl 6 Pg. 35-40 (Dec 1999) ISSN: 0951-3590 ENGLAND
PMID10862267 (Publication Type: Journal Article, Review)
Chemical References
  • Contraceptive Agents, Female
  • Progestins
Topics
  • Breast Diseases (drug therapy)
  • Breast Neoplasms (drug therapy)
  • Climacteric (drug effects, physiology)
  • Contraceptive Agents, Female (therapeutic use)
  • Endometrial Hyperplasia (drug therapy)
  • Endometrial Neoplasms (drug therapy)
  • Endometriosis (drug therapy)
  • Female
  • Humans
  • Menstruation Disturbances (drug therapy)
  • Osteoporosis (prevention & control)
  • Ovarian Neoplasms (diagnosis)
  • Premenopause
  • Premenstrual Syndrome (drug therapy)
  • Progestins (therapeutic use)