HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Human post-mortem striatal alpha4beta2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome.

Abstract
The density of nicotinic alpha4beta2 receptors, which are believed to largely mediate nicotine's effects, has been reported to be decreased in post-mortem hippocampus of patients with schizophrenia. In the present study, using [(3)H]cytisine as a radioligand, we observed a significant 30% decrease in post-mortem striatum of patients with schizophrenia (n=12) as compared to controls (n=12). A 25% decrease of striatal alpha4beta2 receptor density in patients with Parkinson's syndrome (n=12) was not significant. As an upregulation of alpha4beta2 receptors has been observed due to nicotine consumption, the beneficial effects of nicotine described in patients with schizophrenia may be partly due to a compensation for a decrease in alpha4beta2 nicotinic acetylcholine receptors.
AuthorsN Durany, R Zöchling, K W Boissl, W Paulus, G Ransmayr, T Tatschner, W Danielczyk, K Jellinger, J Deckert, P Riederer
JournalNeuroscience letters (Neurosci Lett) Vol. 287 Issue 2 Pg. 109-12 (Jun 23 2000) ISSN: 0304-3940 [Print] IRELAND
PMID10854724 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkaloids
  • Azocines
  • Quinolizines
  • Receptors, Nicotinic
  • nicotinic receptor alpha4beta2
  • Tritium
  • cytisine
Topics
  • Aged
  • Aged, 80 and over
  • Alkaloids
  • Azocines
  • Corpus Striatum (chemistry, metabolism)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease (metabolism, pathology)
  • Quinolizines
  • Radioligand Assay
  • Receptors, Nicotinic (analysis, metabolism)
  • Schizophrenia (metabolism, pathology)
  • Tritium

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: