Neoadjuvant intra-arterial infusion chemotherapy combined with hormonal therapy for locally advanced breast cancer.

Abstract

To determine the efficacy of combined neoadjuvant intra-arterial infusion chemotherapy and hormonal therapy for treating locally advanced breast cancer, we compared the outcomes of patients with or without this therapy, and also assessed histologic response. Ninety-four patients with locally advanced breast cancer (stage IIIa, 56; stage IIIb, 38). Nineteen stage IIIa and 17 stage IIIb patients received intra-arterial plus hormonal therapy while 37 stage IIIa and 21 stage IIIb patients with similar ages and follow-up durations did not. Treated patients received intra-arterial epirubicin plus oral medroxy-progesterone. Five-year disease-free survival rates were 77.5% for intra-arterially treated and 33.0% for other patients in stage IIIa, and 70.5% for intra-arterially treated and 38.1% for other patients in stage IIIb. Five-year overall survival rates were 94.4% for intra-arterially treated and 61.7% for other patients in stage IIIa, and 90.9% for intra-arterially treated and 56.3% for other patients in stage IIIb. Ten-year overall survival rates in stage IIIb were 90.9% for treated and 22.5% for other group patents. All differences were statistically significant (p<0.05). Good histologic response to intra-arterial therapy was seen in 75% of the primary tumors and 71% of involved lymph nodes. Neoadjuvant intra-arterial therapy with hormonal therapy yielded better survival rates than no intra-arterial therapy or our previous intra-arterial regimen.

• Authors: Y Yuyama, A Yagihashi, K Hirata, T Ohmura, Y Suzuki, J Okamoto, T Yamada, Y Okazaki, Y Watanabe, A Okazaki, K Toda, M Okazaki, T Yajima, H Kameshima, J Araya, N Watanabe
• Journal: Oncology reports (Oncol Rep) 2000 Jul-Aug Vol. 7 Issue 4 Pg. 797-801 ISSN: 1021-335X [Print] Greece
• PMID: 10854547 (Publication Type: Journal Article)

Chemical References

• Epirubicin
• Medroxyprogesterone Acetate
• Fluorouracil

Topics

• Administration, Oral
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (drug therapy, mortality, pathology, surgery)
• Chemotherapy, Adjuvant
• Combined Modality Therapy
• Disease-Free Survival
• Epirubicin (administration & dosage, therapeutic use)
• Female
• Fluorouracil (administration & dosage)
• Follow-Up Studies
• Humans
• Infusions, Intra-Arterial
• Lymphatic Metastasis
• Medroxyprogesterone Acetate (administration & dosage, therapeutic use)
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Survival Rate