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[An investigation of serum soluble interferon receptor levels in patients with renal cell carcinoma].

AbstractOBJECTIVE:
Serum soluble interferon alpha/beta receptor (s-IFN-receptor) levels were determined in renal cell carcinoma (RCC) patients to study the clinical significance of the measurement.
SUBJECTS AND METHODS:
S-IFN-receptor levels were measured in RCC patients (n = 27) and healthy volunteers (n = 22) by enzyme immunoassay technique.
RESULTS:
Significantly higher serum s-IFN-receptor levels were observed in RCC patients compared with the healthy volunteers (p < 0.003). The high s-IFN receptor levels in the patients suggested seriousness and mal-prognosis of this disease. The 4-years survival rate of the higher level group (with the mean value of 2.7 +/- 1.7 ng/ml or more) was 53.3%, while the lower level group's rate was 78.7% (Statistical analysis result by Logrank (Mantel-Cox) test; p = 0.4289).
CONCLUSION:
Further study in more subjects is required to determine the feasibility of the s-IFN receptor levels as a prognosis marker, since correlation between the prognosis and s-IFN receptor level was not clarified by this study result.
AuthorsT Iseda, M Yokoyama, H Kanayana, Y Oomoto, S Kagawa
JournalNihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) Vol. 91 Issue 5 Pg. 514-9 (May 2000) ISSN: 0021-5287 [Print] Japan
PMID10853333 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Biomarkers
  • Receptors, Interferon
  • Receptor, Interferon alpha-beta
Topics
  • Aged
  • Biomarkers (blood)
  • Carcinoma, Renal Cell (diagnosis, mortality)
  • Female
  • Humans
  • Kidney Neoplasms (diagnosis, mortality)
  • Male
  • Middle Aged
  • Prognosis
  • Receptor, Interferon alpha-beta
  • Receptors, Interferon (blood)
  • Survival Rate

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