Abstract | OBJECTIVE: SUBJECTS AND METHODS: S-IFN-receptor levels were measured in RCC patients (n = 27) and healthy volunteers (n = 22) by enzyme immunoassay technique. RESULTS: Significantly higher serum s-IFN-receptor levels were observed in RCC patients compared with the healthy volunteers (p < 0.003). The high s-IFN receptor levels in the patients suggested seriousness and mal-prognosis of this disease. The 4-years survival rate of the higher level group (with the mean value of 2.7 +/- 1.7 ng/ml or more) was 53.3%, while the lower level group's rate was 78.7% (Statistical analysis result by Logrank (Mantel-Cox) test; p = 0.4289). CONCLUSION: Further study in more subjects is required to determine the feasibility of the s-IFN receptor levels as a prognosis marker, since correlation between the prognosis and s-IFN receptor level was not clarified by this study result.
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Authors | T Iseda, M Yokoyama, H Kanayana, Y Oomoto, S Kagawa |
Journal | Nihon Hinyokika Gakkai zasshi. The japanese journal of urology
(Nihon Hinyokika Gakkai Zasshi)
Vol. 91
Issue 5
Pg. 514-9
(May 2000)
ISSN: 0021-5287 [Print] Japan |
PMID | 10853333
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers
- Receptors, Interferon
- Receptor, Interferon alpha-beta
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Topics |
- Aged
- Biomarkers
(blood)
- Carcinoma, Renal Cell
(diagnosis, mortality)
- Female
- Humans
- Kidney Neoplasms
(diagnosis, mortality)
- Male
- Middle Aged
- Prognosis
- Receptor, Interferon alpha-beta
- Receptors, Interferon
(blood)
- Survival Rate
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