Neuroprotective effect of retro-inverso Prosaptide D5 on focal cerebral ischemia in rat.

Abstract

Prosaposin (the precursor of saposins A-D) has been identified as a neurotrophic factor in vitro and in vivo. In this study, a novel 11-mer retro-inverso peptidomimetic, Prosaptide D5, was injected i.m. to assess its effectiveness in a rat ischemic model produced by reversible total occlusion of the left middle cerebral artery (MCA). Prosaptide (300 microg/kg, i.m.) injected 3 h after reversible occlusion reduced brain infarct area by 56% compared with a saline group (p < 0.01) at 21 h of reperfusion. A similar injection of D5 6h after occlusion produced a 32% decrease.

• Authors: A G Lu, D A Otero, M Hiraiwa, J S O'Brien
• Journal: Neuroreport (Neuroreport) Vol. 11 Issue 8 Pg. 1791-4 (Jun 05 2000) ISSN: 0959-4965 [Print] England
• PMID: 10852246 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nerve Growth Factors
• Neuroprotective Agents
• prosaptide D5

Topics

• Amino Acid Sequence (genetics)
• Animals
• Brain Edema (pathology)
• Brain Ischemia (pathology)
• Cerebral Infarction (pathology)
• Male
• Molecular Sequence Data
• Nerve Growth Factors (genetics, pharmacokinetics, pharmacology)
• Neuroprotective Agents (pharmacokinetics, pharmacology)
• Rats
• Rats, Sprague-Dawley