Abstract | PURPOSE:
Botulinum toxin (BTX), injected into the ipsilateral medial rectus muscle, has been advocated for the management of acute traumatic sixth nerve palsy or paresis. We conducted a multicenter, nonrandomized, data collection study to evaluate recovery rates of patients treated with either conservative measures or BTX. METHODS: All members of the American Association for Pediatric Ophthalmology and Strabismus and the North American Neuro-Ophthalmology Society were invited to enroll patients with acute traumatic sixth nerve palsy or paresis during a 2-year period (between March 1996 and February 1998). The BTX group was defined as patients who received a BTX injection within 3 months of injury. Recovery at 6 months from injury was defined as absence of diplopia in the primary position and a distance esotropia of no more than 10 PD in the primary position. Nonrecovered patients with less than 6 months of follow-up (n = 15) were excluded. RESULTS: Eighty-four eligible patients were enrolled by 46 investigators. Sixty-two patients (74%) were treated conservatively and 22 (26%) with BTX. Sixty-two patients (74%) had unilateral palsy, and 22 (26%) had bilateral palsy. Recovery rates were similar between BTX and conservatively treated patients (overall: 73% vs 71%, P = 1.0; unilateral: 81% vs 83%, P = 1.0; bilateral: 50% vs 38%, P = 0.66, respectively). CONCLUSIONS: In this prospective multicenter study of acute traumatic sixth nerve palsy or paresis, patients treated with either BTX or conservative measures had similar high recovery rates.
|
Authors | J M Holmes, R W Beck, K E Kip, P J Droste, D A Leske |
Journal | Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
(J AAPOS)
Vol. 4
Issue 3
Pg. 145-9
(Jun 2000)
ISSN: 1091-8531 [Print] United States |
PMID | 10849389
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Anti-Dyskinesia Agents
- Botulinum Toxins
|
Topics |
- Abducens Nerve Injury
(complications, drug therapy, physiopathology)
- Acute Disease
- Adolescent
- Adult
- Aged
- Anti-Dyskinesia Agents
(administration & dosage, therapeutic use)
- Botulinum Toxins
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Craniocerebral Trauma
(complications)
- Diplopia
(drug therapy, etiology, physiopathology)
- Esotropia
(drug therapy, etiology, physiopathology)
- Eye Movements
(drug effects)
- Female
- Humans
- Injections
- Male
- Middle Aged
- Oculomotor Muscles
(drug effects, innervation)
- Prospective Studies
- Treatment Outcome
- Vision, Binocular
|