Abstract | BACKGROUND: AIMS: To investigate the anti-inflammatory profile of ridogrel. METHODS: The effects of ridogrel on the production of eicosanoids, reactive oxygen metabolites and cytokines by cultured inflamed colorectal mucosal biopsies were made using ELISA and chemiluminescence, reactive oxygen metabolite generation in a cell-free system, and platelet activation using flow cytometry. The effects of oral ridogrel on mucosal release of eicosanoids in two patients with active ulcerative colitis were assessed using rectal dialysis. RESULTS: CONCLUSIONS:
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Authors | E Carty, M Macey, S A McCartney, D S Rampton |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 14
Issue 6
Pg. 807-17
(Jun 2000)
ISSN: 0269-2813 [Print] England |
PMID | 10848666
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Eicosanoids
- Gastrointestinal Agents
- Pentanoic Acids
- Pyridines
- Reactive Oxygen Species
- Thromboxane B2
- Dinoprostone
- ridogrel
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Topics |
- Adult
- Cytokines
(analysis, biosynthesis)
- Dinoprostone
(metabolism)
- Eicosanoids
(analysis, biosynthesis)
- Female
- Gastrointestinal Agents
(pharmacology)
- Humans
- Inflammatory Bowel Diseases
(drug therapy, immunology, physiopathology)
- Intestinal Mucosa
(drug effects, physiology)
- Male
- Middle Aged
- Pentanoic Acids
(pharmacology)
- Platelet Activation
- Pyridines
(pharmacology)
- Reactive Oxygen Species
- Thromboxane B2
(metabolism)
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