Abstract | BACKGROUND: Few data are available on the efficacy of second-line H. pylori eradication regimens. AIM: PATIENTS AND METHODS: STATISTICS: t-test, chi2-test. RESULTS: A total of 143 patients had a post-treatment endoscopy. Eradication rates were: intention-to-treat: group O 77% (67-87), group R 76% (66-85), P=0.85; per protocol analysis: group O 86% (77-95), group R 82 (71-93), P=0.58. Side-effects were frequent but mild. CONCLUSIONS:
Omeprazole 20 mg b.d. and ranitidine 300 mg b.d. were equally effective as antisecretory agents combined in a second-line quadruple eradication regimen.
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Authors | S Michopoulos, P Tsibouris, H Bouzakis, A Balta, J Vougadiotis, N Broutet, N Kralios |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 14
Issue 6
Pg. 737-44
(Jun 2000)
ISSN: 0269-2813 [Print] England |
PMID | 10848657
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Organometallic Compounds
- Metronidazole
- Ranitidine
- Tetracycline
- bismuth tripotassium dicitrate
- Omeprazole
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Topics |
- Administration, Oral
- Adult
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Ulcer Agents
(administration & dosage, pharmacology, therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Duodenal Ulcer
(etiology)
- Duodenitis
(etiology)
- Female
- Gastric Acid
(metabolism)
- Helicobacter Infections
(drug therapy)
- Helicobacter pylori
(drug effects)
- Humans
- Male
- Metronidazole
(administration & dosage)
- Middle Aged
- Omeprazole
(administration & dosage, pharmacology, therapeutic use)
- Organometallic Compounds
(administration & dosage)
- Ranitidine
(administration & dosage, pharmacology, therapeutic use)
- Tetracycline
(administration & dosage)
- Treatment Outcome
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