Abstract | BACKGROUND: METHOD: The response of 13 female outpatients with binge-eating disorder by DSM-IV criteria to naturalistic, open-label treatment with topiramate (100-1400 mg/day) was reviewed. Response of binge-eating disorder symptoms was clinically assessed as none, mild, moderate, marked, or remission. Weight and side effects were also evaluated. RESULTS: All 13 patients had comorbid Axis I psychiatric disorders along with binge-eating disorder and were receiving psychotropic medications at the time of topiramate administration. After beginning topiramate treatment, 9 patients displayed a moderate or better response of binge-eating disorder symptoms that was maintained for periods ranging from 3 to 30 months (mean +/- SD = 18.7+/-8.0 months). Two other patients displayed moderate or marked responses that subsequently diminished. The remaining 2 patients had a mild or no response. The mean +/- SD weight of the 13 patients decreased from 99.3+/-26.4 kg to 87.5+/-20.4 kg (z = -2.4, df = 1, p = .02), but only 7 patients lost > or = 5 kg of weight. The mean topiramate treatment dose was 492.3+/-467.8 mg/day for all 13 patients. The mean topiramate dose was higher in patients who lost > or = 5 kg than in patients who lost < 5 kg. Also, topiramate dose correlated significantly with weight loss (p < .01). In general, topiramate was well tolerated, with neurologic side effects the most common. Of 3 patients who discontinued topiramate because of side effects, 2 resumed the drug at a later date without significant recurrence of these effects. CONCLUSION:
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Authors | N A Shapira, T D Goldsmith, S L McElroy |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 61
Issue 5
Pg. 368-72
(May 2000)
ISSN: 0160-6689 [Print] United States |
PMID | 10847312
(Publication Type: Case Reports, Clinical Trial, Journal Article)
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Chemical References |
- Anticonvulsants
- Psychotropic Drugs
- Topiramate
- Fructose
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Topics |
- Ambulatory Care
- Anticonvulsants
(therapeutic use)
- Body Mass Index
- Comorbidity
- Drug Administration Schedule
- Drug Therapy, Combination
- Feeding and Eating Disorders
(drug therapy, epidemiology)
- Female
- Fructose
(analogs & derivatives, therapeutic use)
- Humans
- Mental Disorders
(drug therapy, epidemiology)
- Middle Aged
- Psychotropic Drugs
(therapeutic use)
- Research Design
(standards)
- Severity of Illness Index
- Topiramate
- Treatment Outcome
- Weight Loss
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