Abstract |
Using an organ bath model with porcine cavernosal tissue strips and an in vivo monkey model we demonstrated that abanoquil, a novel alpha adrenoceptor antagonist, is able to relax contracted tissue strips and induce erectile response when injected intracorporally. The erectile response in the monkeys was not dose-related and compared to the effect of papaverine injections, abanoquil induced a lower level of tumescence and rigidity. Hence, abanoquil might be useful as a facilitator of erection in the pharmacological treatment of erectile dysfunction.
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Authors | A Giraldi, M Wyllie, G Wagner |
Journal | International journal of impotence research
(Int J Impot Res)
Vol. 12 Suppl 1
Pg. S37-40
(Mar 2000)
ISSN: 0955-9930 [Print] England |
PMID | 10845763
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Adrenergic alpha-Antagonists
- Aminoquinolines
- Tetrahydroisoquinolines
- Papaverine
- abanoquil
- Norepinephrine
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Topics |
- Adrenergic alpha-Antagonists
(administration & dosage, pharmacology)
- Aminoquinolines
(administration & dosage, pharmacology)
- Animals
- Macaca fascicularis
- Male
- Muscle Contraction
(drug effects)
- Muscle, Smooth
(drug effects, physiology)
- Norepinephrine
(pharmacology)
- Papaverine
(pharmacology)
- Penile Erection
(drug effects)
- Penis
(drug effects, physiology)
- Swine
- Tetrahydroisoquinolines
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