Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue.

Abstract

Using an organ bath model with porcine cavernosal tissue strips and an in vivo monkey model we demonstrated that abanoquil, a novel alpha adrenoceptor antagonist, is able to relax contracted tissue strips and induce erectile response when injected intracorporally. The erectile response in the monkeys was not dose-related and compared to the effect of papaverine injections, abanoquil induced a lower level of tumescence and rigidity. Hence, abanoquil might be useful as a facilitator of erection in the pharmacological treatment of erectile dysfunction.

• Authors: A Giraldi, M Wyllie, G Wagner
• Journal: International journal of impotence research (Int J Impot Res) Vol. 12 Suppl 1 Pg. S37-40 (Mar 2000) ISSN: 0955-9930 [Print] England
• PMID: 10845763 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Aminoquinolines
• Tetrahydroisoquinolines
• Papaverine
• abanoquil
• Norepinephrine

Topics

• Adrenergic alpha-Antagonists (administration & dosage, pharmacology)
• Aminoquinolines (administration & dosage, pharmacology)
• Animals
• Macaca fascicularis
• Male
• Muscle Contraction (drug effects)
• Muscle, Smooth (drug effects, physiology)
• Norepinephrine (pharmacology)
• Papaverine (pharmacology)
• Penile Erection (drug effects)
• Penis (drug effects, physiology)
• Swine
• Tetrahydroisoquinolines