| Abstract | This study was carried out in order to investigate the relationship between endogenous sex steroid hormones and coronary artery disease (CAD). Three hundred and thirty-seven men undergoing coronary angiography were enrolled in the study. Total testosterone, estradiol, free testosterone levels in men with CAD (n = 213) were compared to those of men without CAD (n = 124). No significant differences were found in the serum concentrations of estradiol, total and free testosterone and serum lipid profile between the two groups. Total and free testosterone were negatively (p < 0.05 to p < 0.001) and estradiol was positively (p < 0.05) correlated with age in both groups. Total cholesterol and low-density-lipoprotein levels were positively correlated with the level of free testosterone (r = 0.221, p < 0.01; r = 0.173, p < 0.05, respectively), and high-density-lipoprotein levels were negatively correlated with total testosterone in patients with CAD (r = -0.166, p < 0.05). The results of this study do not support the role of sex steroid hormones in CAD. However, the relationship between sex steroids and serum lipids needs further clarification. |
| Authors | G Kabakci, A Yildirir, I Can, I Unsal, B Erbas
(Affiliation: Hacettepe University, Department of Cardiology, Ankara, Turkey. ayliny at ato.org.tr)
|
| Journal | Cardiology
(Cardiology)
Vol. 92
Issue 4
Pg. 221-5
( 1999)
ISSN: 0008-6312 SWITZERLAND |
| PMID | 10844380
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
|
| Chemical References |
- Biological Markers
- Lipoproteins
- Lipoproteins, HDL
- Lipoproteins, LDL
- Triglycerides
- Estradiol
- Testosterone
|
| Topics |
- Adult
- Age Distribution
- Aged
- Biological Markers
(analysis)
- Coronary Angiography
- Coronary Artery Disease
(blood, epidemiology, radiography)
- Estradiol
(analysis, blood)
- Humans
- Incidence
- Lipoproteins
(analysis, blood)
- Lipoproteins, HDL
(analysis, blood)
- Lipoproteins, LDL
(analysis, blood)
- Male
- Middle Aged
- Probability
- Radioimmunoassay
- Reference Values
- Risk Factors
- Testosterone
(analysis, blood)
- Triglycerides
(analysis, blood)
|
