The first synthesis of clausenamine-A and cytotoxic activities of three biscarbazole analogues against cancer cells.

Abstract

Clausemine-A (3), isolated from the stem and root bark of Clausena excavata, was synthesized using Suzuki cross-coupling and Oxidative coupling as the key step. Compound 3, and the other two structurally related biscarbazoles 1 and 2, showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.

• Authors: A Zhang, G Lin
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 10 Issue 10 Pg. 1021-3 (May 15 2000) ISSN: 0960-894X [Print] England
• PMID: 10843207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Carbazoles
• clausenamine A

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Carbazoles (chemical synthesis, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Tumor Cells, Cultured