Abstract | PURPOSE: METHODS: In vivo measurements of GABA, homocarnosine, and pyrrolidinone were made of a 14-cc volume in the occipital cortex by using a 1H spectroscopy with a 2.1-Tesla magnetic resonance spectrometer and an 8-cm surface coil. Six patients (four women) were studied serially after the first oral dose (1,200 mg) of GBP. Five patients (three women) taking a standard daily dose (range, 1,200-2,000 mg) of GBP were rechallenged with a single high dose (2,400 mg). RESULTS: The first dose of GBP increased median brain GABA by 1.3 mM (range, 0.4-1.8 mM) within 1 h. Homocarnosine and pyrrolidinone did not change significantly by 5 h. Daily GBP therapy increased GABA (0.5 mM; 95% CI, 0.2-0.9), homocarnosine (0.3 mM; 95% CI, 0.2-0.4), and pyrrolidinone (0.10 mM; 95% CI, 0.06-0.14). Rechallenging patients taking GBP daily increased median brain GABA by 0.4 mM (range, 0.3-0.5) within 1 h. CONCLUSIONS:
|
Authors | O A Petroff, F Hyder, D L Rothman, R H Mattson |
Journal | Epilepsia
(Epilepsia)
Vol. 41
Issue 6
Pg. 675-80
(Jun 2000)
ISSN: 0013-9580 [Print] United States |
PMID | 10840398
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Acetates
- Amines
- Anticonvulsants
- Cyclohexanecarboxylic Acids
- Pyrrolidinones
- homocarnosine
- gamma-Aminobutyric Acid
- Gabapentin
- Carnosine
|
Topics |
- Acetates
(pharmacology, therapeutic use)
- Adult
- Amines
- Anticonvulsants
(pharmacology, therapeutic use)
- Brain Chemistry
(drug effects)
- Carnosine
(analogs & derivatives, analysis)
- Cyclohexanecarboxylic Acids
- Dose-Response Relationship, Drug
- Epilepsy
(drug therapy, metabolism)
- Female
- Gabapentin
- Humans
- Male
- Middle Aged
- Occipital Lobe
(chemistry, drug effects)
- Pyrrolidinones
(analysis)
- gamma-Aminobutyric Acid
(analysis)
|