Abstract | BACKGROUND: METHODS: Two-hour total hepatic vascular exclusion was used. Eighteen beagle dogs were randomly assigned to 2 groups: 12 animals were not treated (group I) and 6 were treated with nicaraven (group II). Nicaraven was administered intravenously (2mg/kg/min) for 60 minutes before ischemia and for 3 hours, starting 30 minutes before reperfusion. RESULTS: Two-week survival rates were 25% in group I and 100% in group II (P <.01). Nicaraven inhibited lipid peroxidation in the liver, improved hepatic and systemic hemodynamics and energy metabolism, and suppressed liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver. CONCLUSIONS:
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Authors | R Yokota, M Fukai, T Shimamura, T Suzuki, Y Watanabe, K Nagashima, A Kishida, H Furukawa, T Hayashi, S Todo |
Journal | Surgery
(Surgery)
Vol. 127
Issue 6
Pg. 661-9
(Jun 2000)
ISSN: 0039-6060 [Print] United States |
PMID | 10840362
(Publication Type: Journal Article)
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Chemical References |
- Adenine Nucleotides
- Endothelin-1
- Free Radical Scavengers
- Niacinamide
- Hydroxyl Radical
- Indocyanine Green
- nicaraven
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Topics |
- Adenine Nucleotides
(metabolism)
- Animals
- Dogs
- Endothelin-1
(blood)
- Female
- Free Radical Scavengers
(pharmacology)
- Hemodynamics
(drug effects)
- Humans
- Hydroxyl Radical
(metabolism)
- Indocyanine Green
- Lipid Peroxidation
(drug effects)
- Liver
(drug effects, injuries, metabolism)
- Liver Circulation
(drug effects)
- Liver Transplantation
- Niacinamide
(analogs & derivatives, pharmacology)
- Organ Preservation
- Reperfusion Injury
(metabolism, pathology, prevention & control)
- Temperature
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